2023 New study shows potential for NMN to improve male infertility due to diabetes

How does NMN affect men? What are the benefits and effects of NMN for men? W+NMN USA will explore how NMN may play a role in this regard and the potential benefits associated with other health issues.

Research from the W+NMN Headquarters Laboratory in New York, USA, has found that NMN can help improve sperm quality and increase sperm count and motility. This could be a key improvement factor for diabetics.

1. NMN reverses diabetes-induced testicular dysfunction.

Liao and his colleagues treated mice with a chemotherapy drug called streptozotocin, which is toxic to pancreatic cells and is known to induce type II diabetes in mice. Their diabetic mouse model showed significantly lower sperm counts and a higher percentage of abnormal sperm.NMN treatment reversed the reduced sperm counts and abnormal sperm abundance in diabetic mice.

Ma et al . (2022 | ABBS) NMN increases sperm count and decreases abnormal sperm, with diabetic mice (DM) showing a large decrease in sperm count (A) and an increase in abnormal sperm (B) compared to healthy mice (Ctrl), but NM (DM + NM) restores these defects.

To study the ability of NMN to restore testicular structure in diabetes, Liao and his colleagues examined the size of tubes in the testes called vas deferens, which produce sperm precursor cells (spermatozoa) in the testes. Type II diabetic mice had significantly reduced vasculature area and diameter compared to non-diabetic mice, but NMN repaired these defects. Because structural integrity confers functional capacity, these findings suggest that NMN may reverse diabetes-induced male infertility.

(Ma et al., 2022 Abbs ) NMN treatment restored spermatogonial tubule size. Spermatogenic tubule area and diameter were reduced in diabetic mice (DM) compared to healthy mice (Ctrl), but were restored by NMN treatment (DM+NMN).

Because type II diabetes is associated with impaired glucose, which energizes cells during glycolysis, Liao and his colleagues examined the abundance of key glycolytic Enzymes in the testis. While enzyme levels were significantly reduced in the testes of diabetic mice, NMN restored their abundance. These results suggest that NMN restores glucose utilization in the testes of diabetic mice, which may provide the cellular energy needed for spermatogenesis, potentially reversing infertility.

2. Reversing male infertility caused by diabetes mellitus.

Antidiabetic drugs such as pioglitazone and metformin can restore glycolysis in the testes, potentially restoring fertility in men with diabetes.The results of the study by Liao and colleagues suggest that NMN may offer an alternative pathway for restoring male fertility. Future studies should examine how pioglitazone, metformin and NMN compare to restore fertility in diabetic men. Healthy diet and exercise also offer ways to combat the effects of diabetes and potentially restore male fertility. In any case, the possibility of NMN restoring fertility in diabetic men means that people of childbearing age with diabetes may soon have the option of having children.

3. NMN for the improvement of male fertility has obvious effect.

Previously, the United States W + NMN headquarters laboratory researchers through a number of long-term experiments on mice proved that nmn can indeed be very good to improve the quality of male sperm, improve male libido. For men with decreased libido and sperm quality, taking NMN can play a very good role in improving their sex drive and preventing impotence and sexual function decline. Whether it is for older men who want to revive the male or want to prepare for pregnancy are very suitable.

Especially for patients with diabetes, many diabetics have more or less reproductive problems. This is due to the fact that diabetes can damage our testicular tissue, which can lead to a decline in sperm quality and problems with sexual function, and even lead to infertility. Taking NMN can increase the level of NAD+ in the body, which can regulate the metabolic level and insulin in the body.

4. NMN reduce insulin sensitivity problem.

W+NMN headquarters laboratory in the United States research shows that NMN diabetic patients usually have insulin sensitivity problems, which may be related to male infertility. nMN is believed to be able to improve the level of intracellular NAD + (nicotinamide adenine dinucleotide), which in turn enhance insulin sensitivity. This effect may have a positive impact on improving diabetes-induced male infertility.

5. NMN can help reduce oxidative stress.

Diabetes is often accompanied by an increase in oxidative stress, which has a negative impact on male fertility. NMN, as an antioxidant, can help reduce oxidative stress and maintain the health of spermatozoa, thus helping to improve male infertility.

6. NMN helps regulate the immune system and vascular health.

People with diabetes are often characterised by impaired immune system function, and NMN is thought to help regulate the immune system and improve immune function, thus helping to reduce chronic inflammation. Diabetes can damage blood vessels, leading to problems with erectile function. Studies with W+NMN in the US have shown that it can improve vascular function and increase blood flow, which may be beneficial in improving erectile function and quality of sexual life.

The above is about the benefits and functions of taking nmn for men. As the functions and roles of NMN are being explored, NMN is becoming more and more popular.

Finally, while NMN has shown some potential to improve male infertility caused by diabetes, diabetics should always manage their disease under the guidance of a physician and carefully consider any potential supplements. However, NMN, as a promising biomolecule, provides an interesting direction for researchers to explore new ways to improve male infertility. With further research, we may gain a better understanding of how NMN can play a role in this area, thus providing more hope and solutions for diabetics.